Hyperbaric oxygen therapy in the management of severe leg ulcers from prolidase deficiency

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Hyperbaric oxygen therapy in the management of severe leg ulcers from prolidase deficiency.

To cite: Vestita M, Giudice G, Bonamonte D. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2016-217329 DESCRIPTION A 31-year-old man presented to our attention showing infected ulcerative lesions with pseudoepitheliomatous hyperplasia of legs and feet, which rendered him unable to walk or to even stand. At the age of 8, he had been diagnosed with prolidase defic...

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Sequential and combined treatment of prolidase deficiency leg ulcers

Background The Authors report a case of chronic cutaneous lesions in a patient affected by prolidase deficiency, a rare disorder inherited through an autosomal recessive gene (50 cases reported). The enzyme prolidase is widely distributed throughout the body and it is important in the recycling of proline and hydroxyproline. Among the clinical presentations, the most striking manifestation is t...

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The treatment of varicose leg ulcers by hyperbaric oxygen.

Hyperbaric oxygen at 2 atmospheres pressure was administered to nineteen cases of chronic varicose leg ulceration. Treatment was given for 2 hr on 5 days of each week. Bacterial infection of the ulcers was suppressed, and drying of the lesions occurred within hours of commencing treatment. Epithelialization of healthy granulation tissue was a constant feature. Simple venous ulcers consistently ...

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Hyperbaric oxygen therapy for diabetic foot ulcers.

Foot ulcers are a common and devastating complication of diabetes. Many patients with diabetic foot ulcers experience significant disability and ultimately require amputation. Despite attentive management with multiple modalities including surgical debridement, relief of pressure, and other standard measures, many diabetic foot ulcers persist as chronic, nonhealing wounds. Hyperbaric oxygen (HB...

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Hyperbaric oxygen therapy for nonhealing vasculitic ulcers.

BACKGROUND Cutaneous nonhealing ulceration is a threatening manifestation of vasculitis. Hyperbaric oxygen (HBO), frequently used as adjuvant therapy for patients with ischaemic ulcers, exerts additional beneficial effects on the vascular inflammatory response. AIM To evaluate the effect of HBO on vasculitis-induced nonhealing skin ulcers. METHODS The study population comprised 35 patients ...

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ژورنال

عنوان ژورنال: BMJ Case Reports

سال: 2017

ISSN: 1757-790X

DOI: 10.1136/bcr-2016-217329